Critical Regulation of Calcium Signaling and NMDA-type Glutamate Receptor In Developmental Neural Toxicity
نویسنده
چکیده
This review attempts to discuss how the potential application of some sophisticated research approaches, e.g., calcium imaging/Ca2+ influx and monitoring gene and/or protein expression levels of receptor subtypes, provides a platform in which preclinical research models can inform clinical interventions and vice versa in the developing brain. This review focuses the discussion on representative general anesthetic agents primarily ketamine as examples of how the Ca2+ influx event and specific receptor subunit expression can be used to dissect relevant mechanisms underlying the etiology of the neurotoxicity associated with developmental exposures to anesthetic agents. Critical Regulation of Calcium Signaling and NMDA-type Glutamate Receptor In Developmental Neural Toxicity
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